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Descriptive and prognostic value of a computational model of metastasis in high-risk neuroblastoma

2020-03-30 oncology Title + abstract only
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High Risk Neuroblastoma (HRNB) is the second most frequent solid tumor in children. Prognosis remains poor despite multimodal therapies. Mathematical models have been developed to describe metastasis, but their prognosis value has yet to be determined and none exists in neuroblastoma. We established such a model for HRNB relying on two coefficients: (growth) and (dissemination). The model was calibrated using diagnosis values of primary tumor size, lactate dehydrogenase circulating levels (LDH...

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