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A Computational Approach for Exploring Herbal Inhibitors of Acetylcholinesterase in Alzheimer's Disease
2020-01-10
pharmacology and therapeutics
Title + abstract only
View on medRxiv
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Alzheimers Disease (AD) is the most common type of age related dementia in the world. Many hypotheses shed light on several reasons that lead to AD development. The cholinergic hypothesis describes that the destruction of an essential neurotransmitter, acetylcholine (AChE) by acetylcholinesterase (AChE) enzyme, leads to the AD onset. The hydrolysis of acetylcholine by excess amount of AChE decreases the amount of acetylcholine in the brain, thus interfering with the normal brain functions. Many ...
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