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Metabolomics pilot study identifies circadian desynchronization and distinct intra-patient variability patterns in critical illness

2019-12-14 intensive care and critical care medicine Title + abstract only
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BackgroundSynchronized circadian rhythms play a key role in coordinating physiologic health. Desynchronized circadian rhythms may predispose individuals to disease or be indicative of underlying disease. Intensive care unit (ICU) patients likely experience desynchronized circadian rhythms due to disruptive environmental conditions in the ICU and underlying pathophysiology. This observational pilot study was undertaken to determine if circadian rhythms are altered in ICU patients relative to heal...

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