Change in gut microbiome precedes symptomatic Alzheimer's disease and is correlated with amyloid-beta accumulation in the brain
Shoubridge, A. P.; Manning, S. K.; Tan, S.; Kidson, S.; Richard, A.; Trinder, J.; Miller, S.; Laver, K.; Rahja, M.; Robertson, J.; Crotty, M.; Taylor, S. L.; Rogers, G. B.
Show abstract
INTRODUCTION: Alzheimer's disease (AD) begins with cerebral amyloid-beta (A{beta}) deposition decades before clinical symptoms. While the microbiota-gut-brain axis has been implicated in AD, its role in this preclinical phase remains unclear. We examined potential links between gut microbiome features and presymptomatic cerebral A{beta} burden. METHODS: Asymptomatic individuals (n=101, median age 70.0 years, 53% female) underwent cognitive assessment, cerebral A{beta} quantification, and stool metagenomic sequencing. Associations between microbial characteristics and A{beta} levels were performed using multivariable-adjusted ordinal logistic regression. RESULTS: Gut microbiota composition varied with A{beta} levels (p(perm)=0.03, R2=0.014). Higher A{beta} was associated with increased Alistipes communis, and decreased Anaerotignum faecicola and Eubacterium rectale, abundance (q<0.001). A{beta}-associated microbiome traits corresponded to lower biosynthetic capacity for {gamma}-aminobutyric acid, and systemic regulators of immunity and autophagy (q<0.01). DISCUSSION: Early A{beta} accumulation is associated with distinct gut microbial signatures and reduced neuroactive metabolic potential, identifying targets for potential preclinical AD intervention.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 implicated in Tau pathology 93%
- Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels 92%
- Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease 92%
Similar papers in this journal
- Differences in AD-related pathology profiles across APOE groups 90%
- Expression of Exosome Biogenesis Genes is Pervasively Altered by Aging in the Mouse and in the Human Brain During Alzheimer’s Disease 90%
- Plasma Level of ATPase Inhibitory Factor 1 (IF1) and intrinsic capacity in community-dwelling older adults: Prospective data from the MAPT Study 90%
Similar papers in this journal
- Probing Gut-Brain Links in Alzheimer’s Disease with Rifaximin 94%
- Differences in Plasma Metabolites Related to Alzheimer's Disease, APOE-e4 Status and Ethnicity 93%
- A metabolite-based machine learning approach to diagnose Alzheimer's-type dementia in blood: Results from the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort 92%
Similar papers in this journal
- D-Methionine Improves Spatial Navigation and Attenuates Oxidative Stress and Amyloid Pathology in a Sex-Specific Manner 94%
- Olfactory impairment is related to tau pathology and neuroinflammation in Alzheimer's disease 93%
- Blood Biomarkers for Diagnosis & Differential Diagnosis of Alzheimers Disease in Real-World Clinical Populations: A Systematic Review 92%