Memory Intraindividual Variability and its Association with Hippocampal Integrity in Older Latino Adults Without Dementia
Gonzalez, A. I.; Tristao-Pereira, C.; Martinez, L.; Ramirez, N. J.; Aquilino Silva, G.; Alcina, J.; Martinez, J. E.; Giudicessi, A.; Ku, V.; Rowe, M. C.; Ramirez-Gomez, L. A.; Saldana, D. G.; Quiroz, Y. T.
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Introduction: Cognitive intraindividual variability (IIV), a measure of fluctuation in performance across time or tasks, is an emerging marker of cognitive decline. However, little is known about within-domain IIV in Latino adults. To address this gap, we examined memory IIV and hippocampal integrity in older Latino individuals. Methods: Sixty-seven participants from the Boston Latino Aging Study underwent cognitive testing and MRI. Linear regressions assessed whether memory IIV was associated with hippocampal volume and hippocampus-cingulum tract fractional anisotropy. Additional analyses evaluated associations using mean memory performance as the outcome. Results: Higher mean performance was associated with greater hippocampal volume (=0.24, p=.03), while memory IIV was not (=0.028, p=.84). Higher memory IIV was associated with lower fractional anisotropy in the hippocampus-cingulum tract (=-0.34, p<.01), while mean performance was not (=-0.07, p=.52). Discussion: Memory IIV may be more closely linked to hippocampal white matter, while mean memory performance may better reflect hippocampal volume.
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