Simulated microgravity induces aging phenotypes in human organoids
Mu, W.-C.; Baechle, J.; Schneider, K.; Fuentealba, M.; Wu, F.; Manwaring-Mueller, M.; Bracey, N.; Chebykin, A.; Saini, A.; Park, J.; Kim, J.; Winer, D. A.; Gale, A. I.; Mason, C.; Davis, M. M.; Furman, D.
Show abstract
Simulated microgravity provides a controlled perturbation for testing how loss of mechanical load affects human tissues. After 24 hours in rotating-wall vessels, neural, cardiac and tonsil organoids developed tissue-specific transcriptional responses that overlapped published spaceflight datasets, accompanied by higher transcriptomic-age estimates in neural and cardiac models, altered cardiac-organoid contraction dynamics and modified tonsil-organoid antiviral gene-expression signatures. These findings establish a multi-organoid framework for studying acute responses to gravitational unloading.
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