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Chemogenetic Hydrogen Sulfide Rescues Vascular Senescence in Ageing

Shabanian, K.; Shabanian, T.; Da Dalt, L.; Colucci, M.; Eroglu, E.; Rodriguez Cetina Biefer, H.; Dzemali, O.; Hermann, M.; Alimonti, A.; Norata, G. D.; Paneni, F.; Ruschitzka, F.; Saeedi Saravi, S. S.

2026-09-30 cell biology
10.64898/2026.09.29.755422 bioRxiv
Show abstract

Vascular senescence is a central driver of whole-body ageing, yet rescue strategies remain limited. Here we show that hydrogen sulfide (H2S) bioavailability declines in ageing and atherosclerosis and is associated with endothelial senescence. Developing a novel remote-control, endothelial-specific, mitochondria-targeted chemogenetic system, we spatiotemporally controlled H2S generation and thereby mitigated endothelial senescence-driven programs and reversed vascular remodeling in aged mice.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.