The Energetic Cost of Building Human Skeletal Muscle
Nikolaidis, M. G.; Paschalis, V.; Margaritelis, N. V.
Show abstract
The energetic cost of building human skeletal muscle has never been explicitly calculated or measured. We developed a quantitative bottom-up accounting model that integrates human skeletal-muscle composition with empirically informed estimates of tissue synthesis, physiological deposition, maintenance during accretion, and diet-induced thermogenesis. The calculation was expressed per kg of wet skeletal muscle and organized into five additive components: stored tissue energy, biochemical synthesis cost, physiological deposition cost, resting maintenance during accretion, and diet-induced thermogenesis. Stored tissue energy was approximately 5670 kJ/kg (1355 kcal/kg). Adding biochemical synthesis cost gave 6340 kJ/kg (1515 kcal/kg). Applying empirically derived deposition-efficiency parameters yielded a physiological deposition requirement of 9780 to 11690 kJ/kg (2338 to 2793 kcal/kg), centrally 10830 kJ/kg (2587 kcal/kg). Adding resting maintenance during accretion and diet-induced thermogenesis produced a final additional metabolizable energy intake of 13410 to 15520 kJ/kg (3204 to 3710 kcal/kg), centrally 14570 kJ/kg (3481 kcal/kg). This value provides a first quantitative reference estimate for the energetic cost of human skeletal-muscle accretion.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- A causal model of human growth and its estimation using temporally-sparse data 91%
- Shortcomings of human-in-the-loop optimization for an ankle-foot prosthesis: a case series 90%
- Contributions of spatial and temporal control of step length symmetry in the transfer of locomotor adaptation from a motorized to a non-motorized split-belt treadmill 89%
Similar papers in this journal
- Human Skeletal Muscle has Large Capacity to Increase Carnosine Content in Response to Beta-Alanine Supplementation. A Systematic Review with Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis 90%
- Precision MRI phenotyping of muscle volume and quality at a population scale 89%
- Differences in player position running velocity at lactate thresholds among male professional German soccer players 89%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.