Non-ablative stereotactic radiosurgery for subgenual cingulate neuromodulation in treatment-resistant depression: a randomized dose-seeking pilot trial
Zhao, Y.; Bai, Y.; Yu, A.; Jin, X.; Zhenxiang, Z.; Zou, F.; Ma, Q.; Wang, B.; Zhu, X.; Yang, Z.; Hang, H.; Wang, Y.; Wang, J.; Wang, C.; Liu, X.; Xu, Y.; Qin, Q.; Sun, G.; Wang, Y.; Qu, B.; Zhang, J.; Zhang, L.; Wu, H.; Adler, J. R.; Pan, L.; Wang, G.
Show abstract
The subgenual anterior cingulate cortex (sgACC) is a key node in treatment-resistant depression (TRD), but precise non-invasive neuromodulation of this target is challenging. Preclinical studies of non-ablative stereotactic radiosurgery (SRS) have shown neuromodulatory ("radiomodulation") effects. In this single-center, double-masked, randomized, dose-seeking pilot trial, nine adults with TRD were randomly assigned to bilateral sgACC radiomodulation at a dose of either 15, 20, or 25 Gy per hemispheric target. Primary endpoints were safety and feasibility; the efficacy endpoint was week-4 change in the Montgomery-Asberg Depression Rating Scale (MADRS). Both primary endpoints were met: the only treatment-related adverse event was transient grade 1 dizziness, with no structural MRI abnormality through week 12. Mean MADRS fell from 33.0 to 17.0 (48.5% reduction); 67% responded and 44% remitted, with benefit sustained to week 12. Resting-state fMRI revealed regional connectivity changes correlating with clinical improvement, with tractography showing streamline counts differing by response status. These first-in-human findings support a larger randomized controlled trial of sgACC radiomodulation for TRD. ClinicalTrial.gov registration: NCT07274917.
Matching journals
The top 15 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- TMS-induced modulation of brain networks and its associations to rTMS treatment for depression: a concurrent fMRI-EEG-TMS study 91%
- Sonication of the Anterior Thalamus with MRI-Guided Low Intensity Focused Ultrasound Pulsation (LIFUP) Changes Pain Thresholds in Healthy Adults: A Double-Blind, Concurrent LIFUP/MRI Study 91%
- Human Applications of Transcranial Temporal Interference Stimulation: A Systematic Review 90%
Similar papers in this journal
- Magnetic seizure therapy and electroconvulsive therapy increase frontal aperiodic activity 92%
- A Randomised, Double-Blind, Sham-Controlled Trial of Deep Brain Stimulation of the Bed Nucleus of the Stria Terminalis for Treatment-Resistant Obsessive-Compulsive Disorder 91%
- Whole-brain Mechanism of Neurofeedback Therapy: Predictive Modeling of Neurofeedback Outcomes on Repetitive Negative Thinking in Depression 91%
Similar papers in this journal
- Cognitive training in Parkinson’s disease induces local, not global, changes in white matter microstructure 87%
- In vivo contactless brain stimulation via non-invasive and targeted delivery of magnetoelectric nanoparticles 86%
- Dynamin-1 is a potential mediator in Cancer-Related Cognitive Impairment 86%
Similar papers in this journal
- Ultrasound Applications in the Treatment of Major Depressive Disorder (MDD): A Systematic Review of Techniques and Efficacy 92%
- Towards individualized deep brain stimulation: A stereoelectroencephalography-based workflow for neurostimulation target identification 89%
- Dose-Escalation Study of Amygdalar Transcranial Focused Ultrasound in Healthy Volunteers 88%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.