Hippocampal Volume Predicts Unhealthy Food-Seeking Trajectories in Insulin-Resistant, but Not Insulin-Sensitive, Youth with Obesity and Depression
KHODAYARI, N.; Branchini, J.; Zhao, M.; Valenzuela, R. J. F.; Springs, Z. A.; Khanna, M.; Patron, D.; Singh, M. K.
Show abstract
Insulin resistance, an often-untreated precursor of type 2 diabetes mellitus (T2DM), is implicated in cognitive decline in adults, yet its impact on the developing brain in youth with obesity remains poorly understood. We investigate whether insulin resistance moderates the relation between hippocampal volume and unhealthy food-seeking in overweight and depressed youth ages 9-17 who completed an oral glucose tolerance test and a cognitive task assessing unhealthy food-seeking motivation at baseline, 6-, and 24-months follow-up, and structural MRI at baseline and 6-months follow-up. Insulin sensitivity moderated this relation: smaller baseline hippocampal subfield volumes predicted increased unhealthy food-seeking over 24 months (ps<0.05). Categorical grouping revealed subfield CA2/3 and 4 volumes predicted this relation among insulin-resistant (ps<0.05), but not insulin-sensitive (ps>0.10), youth, suggesting that threshold criteria for insulin resistance are physiologically meaningful. These findings identify a neuro-metabolic risk phenotype that precedes T2DM and may accelerate unhealthy food-seeking severity in youth with obesity.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Prenatal Selective Serotonin Reuptake Inhibitor Exposure, Depression and Brain Morphology in Middle Childhood: Results from the ABCD Study 92%
- Ketamine improves anhedonic phenotypes across species: Translational evidence from the Probabilistic Reward Task 91%
- Mediation analyses link cardiometabolic factors and liver fat with white matter hyperintensities and cognitive performance: A UK Biobank study 91%
Similar papers in this journal
- Kynurenines Increase MRS Metabolites in Basal Ganglia and Decrease Resting State Connectivity in Frontostriatal Reward Circuitry in Depression 93%
- Investigating resting brain perfusion abnormalities and target-engagement by intranasal oxytocin in women with bulimia nervosa and binge-eating disorder and healthy controls 93%
- Serum Metabolites Associated with Depression and Anxiety in the Hispanic Community Health Study/Study of Latinos 93%
Similar papers in this journal
- Adherence to the Mediterranean Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet and Trajectories of Depressive Symptomatology in Youth 94%
- Estradiol Modulates Resting-State Connectivity in Perimenopausal Depression 93%
- General Anxiety Disorder-7 Questionnaire as a marker of low socioeconomic status and inequity 92%
Similar papers in this journal
- How Images of Food Become Cravingly Salient in Obesity 95%
- Interscapular fat is associated with impaired glucose tolerance and insulin resistance independent of visceral fat mass 91%
- Mice lacking dopamine production in neurotensin receptor 1 neurons voluntarily undergo time-restricted feeding of high fat diet and resist obesity 91%
Similar papers in this journal
- Relationship between impulsivity, uncontrolled eating and body mass index: a hierarchical model 94%
- The neural pathways of change: An fMRI study of the effects of behavioral change suggestions on value-based dietary decision-making. 94%
- Higher BMI, but not obesity-related genetic polymorphisms, correlates with reduced structural connectivity of the reward network 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.