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Number Needed to Vaccinate with a Novel Tuberculosis Vaccine to Prevent Tuberculosis in High-Risk Populations, United States

Rothman, J. E.; Castro, K. G.; Lopman, B.; Gandhi, N. R.; Nelson, K.

2026-05-15 public and global health
10.64898/2026.05.11.26352950 medRxiv
Show abstract

We estimated the number needed to vaccinate (NNV) with an M72/AS01E-like vaccine to prevent one tuberculosis case in U.S. high-risk groups. Targeted vaccination of Mycobacterium tuberculosis-infected persons yielded NNVs of 217 (persons with HIV) to 2,486 (U.S.-born), within the range of established adult vaccines.

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