Higher omega-3 DHA-plasmalogen phospholipid levels across early life mediate the benefits of maternal healthy diet and breastfeeding on infant neurocognition
Vacy, K.; Drummond, K.; Thomson, S.; Gogos, A.; Symeonides, C.; Burgner, D.; Mansell, T.; Saffery, R.; Tang, M. L.; O'Hely, M.; George, A. D.; Paul, S.; Meikle, P.; Boon, W. C.; Burugupalli, S.; Vuillermin, P.; Ponsonby, A.-L.; Barwon Infant Study Investigator Group,
Show abstract
Early-life lipid profiles may influence neurodevelopment, yet the underlying biochemical pathways are not well defined. Using serial lipidomic data from 1,074 mother-child pairs in the Barwon Infant Study, we examined associations between maternal and infant lipid networks and cognitive and language outcomes at two years. A shared lipid network enriched in DHA-carrying phosphatidylethanolamine plasmalogens (PEP-DHA) was associated with higher subsequent cognition and language at age two years. These findings were distinct from total DHA levels alone. Antenatally, maternal PEP-DHA partly mediated the relationship between prenatal diet quality and cognition and language. Postnatally, the beneficial effect of breastfeeding on neurocognition was substantially mediated by PEP-DHA levels in infant plasma at 6 months, while infant PEP-DHA mediated the effect of breastfeeding on receptive language. These findings suggest that DHA-containing plasmalogens may represent key lipid mediators linking early nutrition with optimal neurodevelopment.
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