Back

Social factors and lifespan inequality: a four-way factorial analysis of U.S. lifespan

Caswell, H.

2026-03-12 public and global health
10.64898/2026.03.11.26348159 medRxiv
Show abstract

BackgroundLifespan inequality arises both from heterogeneity (e.g., in sex or race) and from unavoidable individual stochasticity. By treating a heterogeneous population as a mixture we can (and many have) partition variance in lifespan into a between-group component due to heterogeneity and a within-group component due to chance. Until now, such studies have treated factors singly. It is now possible to analyze multiple factors and their contributions to variance. ObjectiveThis paper is the first to exploit the new analysis for multi-factor studies. Multi-factor data are painfully rare, but a remarkable study by Bergeron-Boucher et al. presented U.S. life tables under all 54 combinations of four factors (sex, marital status, education, race). Our objective is to quantify the contributions of these factors and their interactions to lifespan inequality. MethodsThe population is treated as a mixture of 54 groups, with a mixture distribution either flat or proportional to population size of the different factor combinations. Components of the variance in remaining longevity, for starting ages from 30 to 85 years, are calculated using marginal mixture distributions. ResultsEven accounting for four factors and their interactions, between-group heterogeneity accounts for only 7% (population-weighted mixing) to 10% (flat mixing) of lifespan variance. Education and its interactions make the largest contribution. Contributions of two-way, three-way, and four-way interactions are orders of magnitude smaller. This suggests new ways of displaying, summarizing, and interpreting inequality as measured in multi-factor studies. ContributionMulti-factor studies can now be used to identify sources of variance in longevity and other demographic outcomes.

Matching journals

The top 3 journals account for 50% of the predicted probability mass.

1
Demographic Research
11 papers in training set
Top 0.1%
27.6%
2
PLOS ONE
5266 papers in training set
Top 13%
13.6%
3
American Journal of Epidemiology
67 papers in training set
Top 0.1%
13.2%
50% of probability mass above
4
Social Science & Medicine
17 papers in training set
Top 0.1%
5.0%
5
Scientific Reports
3612 papers in training set
Top 29%
3.6%
6
Proceedings of the National Academy of Sciences
2444 papers in training set
Top 19%
2.9%
7
PLOS Computational Biology
1863 papers in training set
Top 13%
2.0%
8
Experimental Gerontology
12 papers in training set
Top 0.1%
2.0%
9
International Journal of Obesity
29 papers in training set
Top 0.3%
1.8%
10
Nature Communications
5641 papers in training set
Top 44%
1.8%
11
Aging Cell
165 papers in training set
Top 2%
1.2%
12
Biology Methods and Protocols
61 papers in training set
Top 1%
1.2%
13
Aging
75 papers in training set
Top 1%
1.1%
14
Annals of Epidemiology
21 papers in training set
Top 0.5%
1.1%
15
Science Advances
1243 papers in training set
Top 27%
1.0%
16
SSM - Population Health
17 papers in training set
Top 0.5%
0.9%
17
BMC Medical Research Methodology
47 papers in training set
Top 1%
0.9%
18
Applied Sciences
25 papers in training set
Top 0.8%
0.9%
19
International Journal of Environmental Research and Public Health
128 papers in training set
Top 5%
0.9%
20
Journal of The Royal Society Interface
235 papers in training set
Top 4%
0.6%
21
eLife
5828 papers in training set
Top 67%
0.6%
22
Journal of Epidemiology and Community Health
34 papers in training set
Top 0.6%
0.6%
23
The American Naturalist
125 papers in training set
Top 2%
0.6%
24
European Journal of Epidemiology
43 papers in training set
Top 0.8%
0.6%
25
Journal of Theoretical Biology
162 papers in training set
Top 2%
0.6%
26
BMC Geriatrics
18 papers in training set
Top 0.5%
0.6%
27
Annals of Internal Medicine
28 papers in training set
Top 0.8%
0.5%
28
PNAS Nexus
159 papers in training set
Top 5%
0.5%
29
Statistical Methods in Medical Research
11 papers in training set
Top 0.3%
0.5%
30
Philosophical Transactions of the Royal Society B
51 papers in training set
Top 1%
0.5%