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Development and application of a Phytochemical Food Database (PhytoFooD) to assess the intake of dietary plant bioactives

Michelini, C.; Rosi, A.; Bergamo, F.; Mignogna, C.; Scazzina, F.; Del Rio, D.; Mena, P.

2026-03-11 nutrition
10.64898/2026.03.10.26348068 medRxiv
Show abstract

Plant-based foods are complex systems, where a multitude of bioactive molecules, such as (poly)phenols and carotenoids are the outcome of endless interactions defining food chemical composition. Significant progress has been made to develop reliable food composition databases that can be used to assess the intake of dietary plant bioactives. However, many lesser-known phytochemicals, like glucosinolates and monoterpenoids are often excluded, also due to the fragmented information available in the literature. Therefore, we present PhytoFooD, a comprehensive phytochemical food database that collects qualitative and quantitative information on 1,067 bioactive compounds in 1,410 plant-based foods. We evaluated the intake of main plant bioactives in European diets and demonstrated the role of concentration variability within foods in intake assessments. This database represents a promising tool for dietary intake assessors and researchers in nutrition, paving the way for a comprehensive and accurate knowledge of our diet and the interconnected health effects of plant bioactives.

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