Slow-SPEED: protocol for three randomised trials of remotely delivered exercise to prevent Parkinsons disease
Oosterhof, T. H.; Mitchell, E.; Ascherio, A.; Aslibekyan, S.; Azoidou, V.; Beasley, K.; Ben-Shlomo, Y.; Bunnik, E.; Carroll, C.; Chahine, L.; Corcos, D.; Janssen Daalen, J. M.; van Dijk, K. D.; Dijkstra, B. W.; Dommershuijsen, L.; Dorsey, R.; Evers, L. J. W.; Helmich, R. C.; Johansson, M.; Norcliffe-Kaufmann, L.; Keavney, J.; Klein, C.; Kmiecik, M. J.; Kustermann, T.; Macklin, E. A.; Marek, K.; Meles, S. K.; Overeem, S.; Philpott, C. M.; Pijpers, A.; Postuma, R. B.; Rowbotham, H. W.; Schootemeijer, S.; Schwarzschild, M. A.; Simuni, T.; Sommerauer, M.; Stefani, A.; Steidel, K.; Verbeek, M.; van
Show abstract
We describe the design of the first non-pharmacological prevention trials of Parkinsons Disease worldwide: the randomised controlled Slow-SPEED trials. The three trials examine the feasibility and preliminary efficacy of a gamified, remotely administered exercise intervention vs. active control program over 18-36 months in the Netherlands (n=110), United Kingdom (n=110) and United States (n=600). Each trial focuses on a complementary prodromal subgroup: isolated/idiopathic REM sleep behavioural disorder, hyposmia, or LRRK2/GBA1 mutation carriers. These trials will provide unique insights for large-scale Parkinsons Disease prevention studies.
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