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Genetic liability to hip osteoarthritis confers neurovascular protection against Alzheimer's disease despite depression-mediated phenotypic comorbidity

2026-03-04 genetic and genomic medicine Title + abstract only
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BackgroundThe relationship between hip osteoarthritis (hip OA) and Alzheimers disease (AD) presents a critical paradox within the emerging "bone-brain axis": widespread phenotypic comorbidity sharply contradicts evolutionary theories of biological antagonism. This study integrates longitudinal and multi-omic analyses to determine whether this clinical overlap masks an underlying genetic neuroprotection. MethodsWe analyzed longitudinal phenotypic data from 261,767 UK Biobank participants using C...

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