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GWAS of amiodarone-induced thyroid dysfunction: Applications for genotype-guided risk stratification

2026-03-03 genetic and genomic medicine Title + abstract only
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BackgroundAmiodarone is a widely used antiarrhythmic which frequently induces thyroid dysfunction, including both amiodarone-induced hypothyroidism (AIH) and thyrotoxicosis (AIT). Whether genetic factors contribute to these adverse drug reactions is unknown. In this study, we aimed to identify genetic variants that influence the risk of amiodarone-induced thyroid dysfunction and to evaluate their potential to support genotype-guided risk screening. MethodsThis pharmacogenetic study comprised tw...

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