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Genetic Evidence for Opposing Associations of Psoriasis and Type 2 Diabetes with Inflammatory Bowel Disease: A Mendelian Randomization Study

2026-02-27 genetic and genomic medicine Title + abstract only
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Inflammatory bowel disease (IBD) frequently co-occurs with immune-mediated and metabolic disorders, but whether these associations reflect shared genetics or causal effects remains unclear. We performed two-sample Mendelian randomization (MR) using large-scale genome-wide association study (GWAS) summary statistics to investigate potential causal effects of immune-mediated diseases and lifestyle traits on IBD, Crohns disease (CD), and ulcerative colitis (UC). SNP-based heritability and genetic c...

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