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Impaired Capillary Endothelial Cell Differentiation Contributes to pulmonary hypertension in a dynamic Capillary-Alveoli Micro-physiological System and animal models

2026-02-25 cardiovascular medicine Title + abstract only
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Pulmonary hypertension (PH) is a progressive condition characterized by increased pulmonary arterial pressure. Endothelial cell dysfunction is one important characteristic of PH. Recently, capillary endothelial cells, including aerocytes (aCaps) and general capillary cell (gCaps), have been detected in developing lungs but their role and the regulatory mechanisms underlying PH remain poorly understood. The goal of this study was to identify changes in Caps and their effects on hypertensive pulm...

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