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Time-to-retraction and likelihood of evidence contamination (VITALITY Extension I): a retrospective cohort analysis

2026-02-24 epidemiology Title + abstract only
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BackgroundThe number of problematic randomized clinical trials (RCTs) has risen sharply in recent decades, posing serious challenges to the integrity of the healthcare evidence ecosystem. ObjectiveTo investigate whether retraction of problematic RCTs could reduce evidence contamination. DesignRetrospective cohort study SettingA secondary analysis of the VITALITY Study database. Participants1,330 retracted RCTs with 847 systematic reviews. MeasurementsThe difference in the median number (and...

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