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Accelerating vaccine trials during an outbreak of Disease-X: the effect of pathogen super-spreading on ring-trial design

2026-02-18 epidemiology Title + abstract only
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The prospective design of vaccine efficacy trials for deployment in outbreaks requires advance consideration of plausible outbreak scenarios, anticipated vaccine characteristics, and logistical and ethical constraints. As part of CEPIs 100 Days Mission to accelerate vaccine development against a novel Disease X, we evaluated trial designs for a hypothetical Nipah-X outbreak. We assumed Nipah-X would share key features with Nipah, including high case fatality rates and substantial super-spreading...

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