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Early Detection of Absurdity Signals in Pharmacovigilance: A Machine Learning Ensemble Approach to Identify Rare Adverse Drug Reactions

2026-02-09 health informatics Title + abstract only
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BackgroundTraditional pharmacovigilance methods based on biostatistical approaches systematically exclude outliers and rare events, potentially missing critical safety signals. These methods fail to detect micro-clusters of adverse events and comorbidity patterns that may indicate serious but low-frequency adverse drug reactions (ADRs). We introduce the concept of absurdity signal detection - the identification of statistically anomalous but clinically significant adverse event patterns that co...

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