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Gut microbiome and metabolome reveal hormone-related and functional alterations in ER-positive breast cancer: a case-control study
2026-02-09
epidemiology
Title + abstract only
View on medRxiv
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The gut microbiome has been linked to breast cancer, largely through microbial functions involved in estrogen metabolism (the "estrobolome"); however, specific microbial targets remain poorly defined in human studies. Here, we profiled the gut microbiome using whole-metagenome shotgun sequencing, and plasma and stool metabolites were quantified using targeted metabolomics, in a study of 70 postmenopausal female cases with treatment-naive ER-positive breast cancer and 70 controls. Reduced species...
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