Back
Top 0.2%
17.4%
Top 3%
17.4%
Top 0.9%
11.6%
Top 0.7%
6.3%
Top 1%
5.9%
Top 52%
5.5%
Top 5%
4.1%
Top 0.5%
3.8%
Top 1%
1.9%
Top 3%
1.9%
Top 0.8%
1.9%
Top 6%
1.5%
Top 8%
1.3%
Top 8%
1.2%
Top 4%
0.9%
Top 2%
0.9%
Top 99%
0.7%
Top 13%
0.7%
Top 1%
0.7%
Top 6%
0.7%
Multi-strain probiotic enhances metformin tolerance by modulating gut microbiome and bile acid pathways: Insight from multi-omics post-hoc analysis (ProGasMet trial)
2026-02-09
endocrinology
Title + abstract only
View on medRxiv
Show abstract
BackgroundMetformin is the cornerstone therapy for type 2 diabetes, but gastrointestinal intolerance commonly limits dose escalation and long-term adherence. In the ProGasMet trial, multi-strain probiotic supplementation improved metformin tolerability. However, the underlying microbiome-metabolome mechanisms remain unclear. Methods and analysisWe performed an exploratory multi-omics analysis using Period 1 of a randomized, double-blind, placebo-controlled trial. Participants with metformin int...
Predicted journal destinations
1
eLife
262 training papers
2
Nature Communications
483 training papers
3
The Journal of Clinical Endocrinology & Metabolism
26 training papers
4
Diabetologia
23 training papers
5
Frontiers in Endocrinology
20 training papers
6
Scientific Reports
701 training papers
7
BMC Medicine
155 training papers
8
Cell Reports Medicine
49 training papers
9
Gut Microbes
15 training papers
10
JCI Insight
63 training papers
11
Communications Medicine
63 training papers
12
Genome Medicine
56 training papers
13
Nature Genetics
72 training papers
14
iScience
74 training papers
15
Nutrients
43 training papers
16
International Journal of Obesity
17 training papers
17
PLOS ONE
1737 training papers
18
eBioMedicine
82 training papers
19
Med
26 training papers
20
eClinicalMedicine
55 training papers