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Biologically informed instrument selection for dietary Mendelian randomization using chemosensory receptor variants

2026-02-06 epidemiology Title + abstract only
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BackgroundMendelian randomization (MR) is increasingly used for causal inference in nutritional epidemiology; however, dietary MR studies often rely on instruments statistically selected from genome-wide association studies of self-reported intake, which are vulnerable to pleiotropy and reverse causation and may violate core MR assumptions. We aimed to develop and evaluate a biologically informed framework for selecting valid genetic instruments for dietary exposures, based on genes encoding tas...

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