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Longitudinal 7T MRS Study of Glutamate and GABA Dynamics in Alzheimer's Disease Progression: From hyper- to hypoexcitation

2026-02-09 neurology Title + abstract only
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Functional neuroimaging studies suggested a biphasic trajectory of neuronal activity in Alzheimers disease (AD), with early hyperactivity followed by later hypoactivity. However, the underlying neurochemical mechanisms in humans remain unclear. Animal studies suggested that amyloid-beta (A{beta}) causes intrasynaptic glutamate increases through impaired astrocytic clearance. This study aimed to build a mechanistic bridge between findings from human neuroimaging studies and preclinical models by ...

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