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In Silico Network Perturbation Reveals Hierarchical Roles of DNA Repair and Glycosylation Linking Exercise to Human Ageing Clocks
2026-02-03
genetic and genomic medicine
Title + abstract only
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Regular physical activity delays biological ageing, yet how transient exercise-induced molecular responses are translated into stable ageing signatures in humans remains unclear. Here, we introduce the first in silico perturbation framework for human exercise biology that integrates genetically anchored gene prioritisation, graph-based network modelling, and human experimental validation. Genes causally associated with habitual vigorous physical activity (VPA) were prioritised using Mendelian ra...
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