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Episodic memory retrieval with increasing task demand: Associations with age, APOE4 genotype, and Alzheimer's disease pathology

2026-01-30 neurology Title + abstract only
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BACKGROUNDEpisodic memory declines early with aging, reflecting reduced neural resources and diminished memory specificity. However, few studies have created a cognitive challenge with multiple levels of task demand to investigate this early subtle decline. Furthermore, it is unclear whether the genetic Alzheimers disease risk factor APOE4 and early Alzheimers pathology constrain the neural resources required to cope with increasing task demands. METHODSIn this preregistered behavioral study na...

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