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Data-driven trajectories of atrophy explain clinical heterogeneity across Lewy body diseases

2026-02-02 neurology Title + abstract only
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Lewy body diseases (LBD) collectively share -synuclein Lewy pathology, yet present wide clinical heterogeneity, with overlapping motor and non-motor features and progression patterns that challenge traditional diagnostic boundaries. To resolve this spatiotemporal heterogeneity at the biological level, we applied a data-driven atrophy progression framework to MRI data from 833 individuals across Parkinsons disease (PD), dementia with Lewy bodies (DLB), and prodromal idiopathic REM sleep behaviour...

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