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Interpreting Breakthrough Infections Given Assortative Mixing of Partially Vaccinated Populations
2026-01-23
public and global health
Title + abstract only
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Declining vaccine coverage across the United States has increased the risk of outbreaks of vaccine-preventable diseases. Even when vaccines have low primary failure rates, conventional epidemic theory predicts a strongly nonlinear, positive relationship between vaccine coverage and the fraction of breakthrough infections in vaccinated individuals. These breakthrough infections may generate misconceptions that vaccines are not working and accelerate declines in confidence and coverage. Here, we s...
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