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Monosodium Urate Crystals within Cardiomyocytes

2026-01-24 cardiovascular medicine Title + abstract only
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BackgroundWhile monosodium urate (MSU) crystal deposition within coronary plaques links hyperuricemia/gout to cardiovascular risk, the existence and functional consequences of MSU deposits within the myocardial interstitium or cardiomyocytes remain unknown. MethodsForensic autopsy myocardial and renal specimens from gout patients (n=4) and controls (n=4) were analyzed for MSU crystals using compensated polarized microscopy, laser capture microdissection coupled with HPLC-MS, and cryo-electron m...

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