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In Silico Optimization Of Biomimetic Nanoparticle Kinetics For Sepsis Management: A Computational Pharmacology Framework For Rational Design

2026-01-19 intensive care and critical care medicine Title + abstract only
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BackgroundSepsis-induced mortality is frequently driven by the systemic dissemination of pore-forming toxins (PFTs), such as Staphylococcus aureus alpha-hemolysin. Biomimetic "nanosponges" which are nanoparticles coated in red blood cell (RBC) membranes have emerged as a promising detoxification strategy. However, current methods rely largely on empirical iteration, often failing to optimize the competitive binding kinetics required to outcompete native RBCs in a high-flow hemodynamic environmen...

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