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Differentiating Borderline HER2-Expressing and HER2-Positive Cancers from Other Subtypes Using Serum Urokinase Plasminogen Activator

2026-01-16 oncology Title + abstract only
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BackgroundHER2-positive (HER2+) cancers are associated with aggressive tumor development but also high response rates to targeted blockade treatments of the HER-2/neu signaling pathway leading to improved clinical outcome for the patient. Current clinical analysis of the HER2 status primarily relies on solid tumor biopsies low-suitable for continuous real-time monitoring needed for possible adjustment of the treatment, while serum tests targeting blood-circulating HER-2/neu fragments often show ...

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