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Aging macaques bridge the translational gap in perivascular space biology

Liguore, W. A.; Schwartz, D. L.; Piantino, J.; Rajendran, A.; Jensen, G.; Karpf, J. A.; Chernov, M. M.; Woltjer, R. L.; Kohama, S. G.; Silbert, L. C.; Weiss, A. R.

2026-01-15 neuroscience
10.64898/2026.01.14.699534 bioRxiv
Show abstract

The prevalence of MR-visible perivascular spaces (PVS) is age-dependent in rhesus macaques. Automated quantification in 94 male and female animals ranging 5-28 years of age demonstrated a robust association between age and PVS burden, with an anatomical distribution paralleling that of humans. Preliminary ex vivo validation confirmed that the MRI-detected tubular structures correspond to perivascular spaces. These findings establish the rhesus macaque as a tractable model for understanding the role of perivascular dysfunction in age-related brain vulnerability.

Published in Scientific Reports (predicted rank #8) · training set

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