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Plasma H3.1-Nucleosomes To Classify Severity And Surrogate Response To Treatment In Hidradenitis Suppurativa: A Cohort Study

2026-01-15 dermatology Title + abstract only
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BackgroundHuge neutrophilic infiltrates within lesional and perilesional tissue in hidradenitis suppurativa (HS) give rise to the hypothesis that neutrophil extracellular trap (NET) formation may further drive systemic immune activation in HS. As intrinsic constituents of NETs, nucleosomes-particularly circulating nucleosome containing Histone H3.1 (H3.1-nucleosomes)-serve as reliable indicators of NETosis in the blood. ObjectivesTo investigate whether plasma H3.1-nucleosomes, fluctuate with HS...

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