Safety and Efficacy of Adjunctive Intra-arterial Adenosine Following Successful Endovascular Thrombectomy in Patients with Large Vessel Occlusion Acute Ischemic Stroke (REACT) Trial: Rationale and Design

2026-01-06 neurology Title + abstract only

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BackgroundAmong patients with acute ischemic stroke (AIS) secondary to large vessel occlusion (LVO) who undergo successful reperfusion following endovascular thrombectomy (EVT), only one-third are disability-free at 90 days, which may be related to persistent microvascular hypoperfusion after thrombectomy known as the "no-reflow phenomenon". Adenosine is administered to prevent percutaneous coronary intervention (PCI)-related no-reflow through microvasculature dilation and neutrophil-mediated in...

Safety and Efficacy of Adjunctive Intra-arterial Adenosine Following Successful Endovascular Thrombectomy in Patients with Large Vessel Occlusion Acute Ischemic Stroke (REACT) Trial: Rationale and Design

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