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Osteoporosis Genetic Risk Prediction Using Bone Mineral Density Polygenic Scores in Japanese: TMM CommCohort Study

2026-01-02 genetic and genomic medicine Title + abstract only
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Osteoporosis and fractures are major health concerns. We developed and validated a polygenic score (PGS) for osteoporosis in a Japanese population using heel quantitative ultrasound-derived T-scores. Genome-wide association study data from 12,371 participants in the Tohoku Medical Megabank Community-Based Cohort identified genome-wide significant loci, including MBL2, TMEM135, and WNT16. PGS models were constructed and evaluated using independent datasets for model selection (n = 1,419) and vali...

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