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Non-specific effects of vaccines on all-cause mortality: a meta-analysis of randomized controlled trials (RCTs) 2012-2025

2026-01-02 epidemiology Title + abstract only
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BackgroundEarly observational studies reported substantial reductions in all-cause mortality, suggesting that childhood vaccines might influence health in ways beyond their targeted disease. Such Non-Specific Effects (NSEs) of vaccines could potentially have important implications for the Expanded Programme of Immunization (EPI). In 2014 World Health Organization (WHO) Strategic Advisory Group of Experts (SAGE) commissioned a review of the NSE evidence, which called for more Randomized Controlle...

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