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The Hippo Pathway Regulates Corneal Endothelial Regeneration

Zhuang, J.; Guo, Y.; Zhang, H.; Zhong, M.; Hu, X.; Zhang, L.; Yu, J.; Wang, Y.; Cai, S.; Wu, H.; Chu, C.; Huang, W.; Quantock, A. J.; Liu, Z.; Li, W.

2025-12-31 cell biology
10.64898/2025.12.30.697046 bioRxiv
Show abstract

Corneal endothelial cells (CECs) have limited regeneration capacity in primates while display a potent restorative capability in some species such as rodents after wounding. The mechanism which determines the regenerative capability of CECs remains poorly understood. Here, we identified that the Hippo pathway was inhibited and the downstream effector YAP was activated during CEC wound healing in rabbits. Knockdown of Yap1 and pharmacological inhibition of YAP suppressed CECs wound healing in rodents in both in vitro and in vivo models. XMU-MP-1, a specific small molecular inhibitor for Hippo pathway, could promote the corneal endothelial regeneration in rodents and corneal endothelial proliferation in cultured primate CECs, as well as in vivo non-human primate CEC wounding model. These findings suggest that Hippo pathway serves as a conserved signal to regulate corneal endothelial regeneration among various species, providing a novel target for non-invasive treatment of corneal endothelium decompensation. One Sentence SummaryThe Hippo pathway regulates corneal endothelial regeneration across species, revealing a therapeutic strategy for corneal endothelial decompensation.

Published in The Ocular Surface · not in our set (fewer than 10 published preprints to learn from) · training set

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The top 7 journals account for 50% of the predicted probability mass.

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Scientific Reports
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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.