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Accelerated electrocardiographic aging of the heart as a risk determinant for atrial fibrillation: A Mendelian randomization study

2025-12-31 cardiovascular medicine Title + abstract only
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BackgroundArtificial intelligence (AI)-derived electrocardiographic aging (ECG-aging) has been found to be associated with the risk of atrial fibrillation (AF). ObjectivesWe aimed to assess the causal association between the discrepancy in AI-predicted electrocardiographic age and chronological age (AI-ECG age gap) and AF risk. MethodsWe analyzed 12-lead ECGs in UK Biobank to derive the AI-ECG age gap using our latest AI-based age prediction model. Associations between measured ECG-aging and g...

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