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Large-scale genetic analysis of AMD drug targets highlights precision therapy opportunities for patients with high polygenic risk

2025-12-29 pharmacology and therapeutics Title + abstract only
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BackgroundIn the past two decades, genetic studies have elucidated the contributions of key biological pathways to the pathogenesis of age-related macular degeneration (AMD), including complement activation, lipoprotein metabolism, angiogenesis, and extracellular matrix maintenance. Of these pathways, complement in particular has been observed to dominate the genetic architecture of AMD. Yet, clinical treatment of AMD with complement inhibitors has met with limited success. MethodsUsing data fr...

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