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Systemic inflammation and increased tryptophan catabolism underpin depression, anxiety, and chronic fatigue symptoms after myocardial infarction: effects of revascularization

2025-12-30 cardiovascular medicine Title + abstract only
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BackgroundPatients with myocardial infarction (MI) often exhibit neuropsychiatric symptoms, but the underlying pathophysiological mechanisms remain elusive. This study examines the roles of the tryptophan catabolite (TRYCAT) pathway, systemic inflammation, and adverse metabolic remodeling in this comorbidity, both before and after percutaneous coronary intervention (PCI). MethodsWe assessed depression, anxiety, and chronic-fatigue syndrome (CFS)-like rating scales, blood levels of TRYCATs, infl...

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