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Assessing the Role of Model Complexity in Virtual Clinical Trial Outcomes
2025-12-27
pharmacology and therapeutics
Title + abstract only
View on medRxiv
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Virtual clinical trials (VCTs) hold significant promise for improving the drug development process, yet their predictive reliability depends critically on design decisions that remain poorly understood. This study examines how model complexity influences VCT outcomes, as well as how the choice of prior parameter distributions and virtual patient inclusion criteria affects those outcomes. Using oncolytic virotherapy treatment of murine tumors as a case study, we compared three mathematical models...
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