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CKS2, ERG28, ERP44, and FAM32A as Therapeutic-Responsive Oncogenic Biomarkers in Adrenocortical Carcinoma: A Multi-Omics, Systems-Level Analysis
2025-12-23
oncology
Title + abstract only
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Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with poor prognosis and limited therapies. To elucidate its post-transcriptional regulation, ceRNA networks were reconstructed from TCGA-ACC and GTEx 2025 data. Tumor networks exhibited compact topology and tumor-specific hub miRNAs (miR-466, miR-940, miR-507), which were downregulated, inversely correlated with oncogenic transcripts, and associated with adverse survival. Candidate targets were identified through dual validation ...
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