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Effectiveness of high-dose versus standard-dose influenza vaccines against severe respiratory and cardiovascular outcomes in adults aged >=80 years, Andalusia, Spain, 2024-2025 season

2025-12-29 public and global health Title + abstract only
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BackgroundVaccination is a key measure to prevent severe influenza in adults aged [≥]80 years, who experience the highest burden of respiratory and cardiovascular complications. Because immunosenescence reduces the effectiveness of standard-dose vaccines (SD-IIV), enhanced formulations such as high-dose vaccines (HD-IIV) are recommended in the elderly. Real-world data on their effectiveness in adults aged [≥]80 years remain scarce. AimTo quantify the relative vaccine effectiveness (rVE) o...

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