IL-32 in limb-girdle muscular dystrophy LGMDR1-calpain 3 related: A Pilot Study on Its Role as a Biomarker
Immanuel, J.; Valls, A.; Ruiz, C.; Poza, J. J.; Garay Albizuri, P.; Fernandez Torron, R.; Lopez de Munain, A.; Saenz, A.
Show abstract
In LGMDR1-Calpain-3 related, as in all muscular dystrophies, clinical trial monitoring remains a challenge due to the lack of reliable biomarkers. This study assessed IL-32 concentrations in both serum and urine, uncovering a marked increase in patients compared to healthy controls. Serum IL-32 levels were especially elevated in young adults, suggesting a possible link to the early and more active phases of disease onset. Meanwhile, urinary IL-32 levels showed consistent elevation across all age groups, reinforcing its promise as a stable, non-invasive biomarker. These findings support the potential of IL-32 in monitoring disease progression and therapeutic response in clinical trials, and underscore its potential involvement in LGMDR1.
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