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Improving Quality of CAR-T Cell Therapy Starting Material with Automated Microfluidic Cell Sorting
2025-12-18
pharmacology and therapeutics
Title + abstract only
View on medRxiv
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Autologous CAR-T cell therapy has demonstrated remarkable clinical efficacy in hematologic malignancies, yet its broader application remains limited by complex, labor-intensive manufacturing and inconsistent product quality. We describe a novel microfluidic cell separation platform based on Deterministic Lateral Displacement (DLD), integrated into a fully automated, closed-system instrument (Curate System), capable of processing full leukopacks in under one hour. Compared to Ficoll(R)-based dens...
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