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Low levels of circulating IgG against bacterial GAPDH and elevated IL-10 levels are associated with increased susceptibility to Escherichia coli bacteraemia
2025-12-17
infectious diseases
Title + abstract only
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BackgroundWhile antimicrobial resistance is an increasingly urgent problem, with Escherichia coli infections representing a major priority, the development of effective vaccines has proven both challenging and largely unsuccessful. Given accumulating evidence supporting the immunosuppressive role of extracellular bacterial glyceraldehyde-3-phosphate dehydrogenase (GAPDH), we aimed to characterize individual susceptibility to E. coli infections based on the presence of naturally induced antibodie...
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