Genetic risk factors for postoperative complications after major surgery and shared genetic aetiology with non-postoperative phenotypes

2025-12-12 anesthesia Title + abstract only

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BackgroundUp to 15% of patients worldwide experience serious postoperative complications after major surgery. We explored the genetic basis of five common postoperative complications and whether they share genetic aetiology with their non-postoperative equivalents. MethodsWe performed case-control genome-wide association studies (GWAS) using UK Biobank data from >140,000 participants. The primary outcomes were postoperative acute kidney injury (AKI), atrial fibrillation (AF), myocardial infarct...

Genetic risk factors for postoperative complications after major surgery and shared genetic aetiology with non-postoperative phenotypes

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