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Limited Generalizability of Epigenetic Clocks and Scores Across Pediatric Tissues and Age Ranges

2025-12-15 pediatrics Title + abstract only
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Epigenetic clocks and scores have been investigated as potential biomarkers of later-life health outcomes following early-life exposures. In pediatric settings, DNA methylation (DNAm) is often measured in saliva; however, most clocks and scores have been trained in adult blood. Therefore, we assessed the performance, correlation, longitudinal stability, and association with early-life adversity (ELA) for established epigenetic measures in matched pediatric blood and saliva samples. Leveraging th...

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